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KMID : 0617219910020010069
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Duksung Bulletin Phamaceutical Sciences
1991 Volume.2 No. 1 p.69 ~ p.74
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Pharmacological of 5-Fluorouracil-Fat Conjugates and Evaluation of their in vitro Cytotoxic Activity
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Abstract
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The FU-fat conjugates(4a-e) as a prodrug have been synthesized by condensing various fatty acids(1a-e) via isocyanates(2a-e) as carbamoyl group at N^1-position of 5-fluorouracil and their structures characterized. Preliminary testing for their antitumor effect was carried out on leukemia L 1210 cells in culture. Most of them(4a-d) like the parent FU exhibited less than 50％ inhibition on grouth of the cultrued cells at the concentration of 1×10^-7 M. Only a dicarboxylic acid derivative, 4e, showed over 50％ inhibition at the same level.
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